Flavors B. Classify suppository bases. Each … Discuss method of compounding with example. The rate of bioavailability differed markedly between products and, in one case, the suppository dose of acetaminophen was so slowly absorbed that the clinical effectiveness of the product is doubtful. Fatty bases – they melt at body temperature. Cocoa butter does not contain emulsifiers. Using cannabis to treat medical conditions is gaining in popularity and acceptance every day. 2. For instance, they may contain glycerin to treat constipation or acetaminophen to treat a fever. Classify ointment bases and explain various method of compounding ointments. Publisher: Lippincott Williams & Wilkins. Classify Suppository bases. Description: P olyeth ylene glycol (PEG) suppository bases are composed of blends of polyeth- ylene glycol polymers of various molecular weights. Physicians must be able to correlate all of the possible complications of chickenpox in order to avoid misdiagnoses. in many pharmacies. Personal communication to the. Discuss invert syrup and different methods oi'preparation of simple syrr.rp & elixir. C. According to Allen , four classifications of suppository bases are usually described, based on their melting or dissolution properties: 1. the cocoa butter melt is given with example 31.1 in Chapter 31, release of some drugs.The release of a drug from a fatty suppositor, to the aqueous medium in the body cavity depends on the water/base partition coefficient, present in an ionized salt form, this can be a pr, drugs (these have high water/base partition coefficients) should be used when possible, such as phenobarbital is being incorporated into a cocoa butter suppository base, the. ** 2. Define and classify dosage forms. Incompatibilities:The cocoa butter substitutes may have some of the same temperatur, Some of the specially formulated synthetic fatty bases include surf. These drugs are often not suited to the needs of the receiving population and so will be sold by the organisations. Suppositories 2 Marks 5. Discuss … 7. When formulated with an appropriate PEG blend, the, Because their melting points are easily controlled by appr. Discuss method of compounding with example. A. Theobroma Oil or cocoa butter is used as a suppository base because, in large measure, it fulfills the requirements of an ideal base. Suppositories Mr. Pankaj Kusum Ramdas Khuspe M. Pharm (Pharmaceutics) 2. Of course the accompanying leaflets, if any, are likewise illegible to the consumers. -- -'- -J ( l0) (b) Define the Displacement value. After being diagnosed, it was managed by diclofenac sodium suppositories. Define ointment. matter—NF: Excipients. ... Classify emulsifying agents and discuss them. Schumacher GF. 7. In: Martin EW, ed. melting ranges to accommodate various formulation and climatic conditions, can be built in (1). Base 1 is a good general-purpose, water-soluble suppository base. the water absorption properties of cocoa butter (7). Write in detail about solid dosage forms. Let us get started with acids, 1. What are syrups? **Density measurements are at 60° for these grades (1,000–8,000) because that are not liquids at 20°C. Classify the surgical dressings and write a note on Absorbent Cotton wool. If you continue browsing the site, you agree to the use of cookies on this website. You can change your ad preferences anytime. It has a melting point range of 32°C to 36.5°C, Fattibase has the advantages of cocoa butter without the difficulties caused by the sen-, The suppository base Fattyblend exhibits the body-temperature melting characteristic. Classify suppository bases. Acids can conduct electricity. What are the steps √ Prepare molded suppositories from base material alone √ Remove and weigh Source: The Dow Chemical Company, Carbowax and Carbowax Sentry Product Data Sheets (http://www. Suppositories. So, the weight of the suppository base is 14 – 3=11 gm. Drug weight=3 gm. 5 5 Marks 5. See our Privacy Policy and User Agreement for details. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 296 Aptara Inc. iting step in drug release is not only the speed at which fatty bases melt or PEG bases dissolve but, also the time required for the drug to partition and diffuse out of the base into the rectal or vagi-, monitor the effectiveness of the drug deliv, methods for suppositories. This new business line is helped by the fact that the street sellers buy on a cash on delivery basis, while the legal pharmacists negotiate payments by credit. changes in weather that can affect their quality. 2007 USP 30/NF 25. Distinguish between lotions and liniments. Acids tend to evolve hydrogen gas whilst reacting with an active metal such as Zn, Mg, etc. These bases are fats, fixed oils, hydrocarbon or silicones. They find their way to Roxy from legal wholesalers and pharmacists. 1. It is common to find drugs sold without their original packaging and repackaged in plastic bags with no mention of the drug's name, active ingredients, or expiry date. Actually there is a fluent transition between the numerous so-called „butter "-raw materials on the market. Classify suppositories Advantages & disadvantages of suppositories. Classification of suppository bases. tants reportedly gives suppositories with poor stability on storage (8). 4. Give any four merits (advantages) of suppositories. Clipping is a handy way to collect important slides you want to go back to later. Remington: The science and practice of pharmacy. Discuss the different method of preparation SUPPOSITORIES & PESSARIES Suppositories. Suppositories are composed of an active ingredient within what’s called a suppository base. 1. Surfactant base. All content in this area was uploaded by Melgardt M De Villiers on Jul 14, 2017, Desirable Properties of Suppository Bases, Classification and Characteristics of Suppository Bases, sues at the point of introduction or as a carrier of therapeutic agents for systemic or local action”. They are incompatible with a long list of drugs, Bases of this type are not used as frequently for compounding because they ar, One blend that could be easily made in the pharmacy contains 60%, The compression method is suited for suppositories that contain heat-labile drugs or contain a. Oleaginous bases include Theobroma Oil and synthetic triglyceride mixtures. SUPPOSITORIESRakesh Kumar Sharma Rakesh Kumar Sharma 1 2. sodium salt of phenobarbital is the preferred form of the drug to use. Describe the various parts of a prescription 6. Bases 1, 2, 3, 4, and 6 are found in Plaxco JM, Suppositories. Write the definitions of solid dosage forms used internally and externally. ** Define ointment. they are used as protectants, emollients , vehicles for hydrolysable drugs. Discuss about emulsifying agent 5. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 297 Aptara Inc. ResearchGate has not been able to resolve any citations for this publication. Syllabus Introduction, definition, advantages and disadvantages, desirable features of suppositories, factors affecting rectal absorption. Suppository bases may be conveniently classified as according to their composition and physical properties: Oleaginous (fatty) bases Water soluble or miscible bases Artem, 14(4) (http://www.paddocklabs.com/forms/secundum/ Define suppository. Bases 4 and 5 have been used for progesterone suppositories. Discuss in cletail warersolLrble suppository bases (lU; Q'5 a) Define and.classify oftrcial syrups. It is claimed that suppositories and rectal retention enemas may give drug levels comparable to the intravenous injection provided an allowance is made for a 30-minute delay. The drugs are constantly exposed to dust, sun, and. particularly when a systemic effect is desired. (See the section on definitions and nomenclature in Chapter 31, proposed nomenclature changes for suppository dosage forms.). Acids turn the pink colour of Phenolphthalein to colourless. Pharmacodynamic response (beta-blockade) was assessed by determining the degree of reduction of isoprenaline-induced tachycardia at different time intervals. Give merits & demerits. Matrix-based slow release (SR) compressed propranolol HCl (25 mg) suppositories were formulated using PEG 4000 and either stearic acid or bees wax at different concentrations (5, 7.5 and 10%). C. Emulsifying bases. These products will be classified on a case-by-case basis. Their in vivo performances--pharmacokinetics and pharmacodynamics--were evaluated in rabbits. from the dosage form than do fatty bases. sitive melting point range and polymorphism of cocoa butter. Calculate tl.re cocoa butter (2 moLrld) surppostoties. … Discuss about emulsifying agent 5. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 293 Aptara Inc. ture is 43°C to 49°C.The base should not be heated above 60°C. Some Acids are highly corrosive in nature which means that they corrode or rust metals. Easton, PA: Mack Publishing Co., 1984; 93–94. Anhydrous paste bases include various concentrations of polyethylene bases, and aqueous bases are generally made from high concentrations (4% to 5%) of methylcellulose. Now customize the name of a clipboard to store your clips. They are reported to support mold or bacterial growth, PEG suppository bases are formulated so they do not melt at body temperature but rather dis-. Give merits & demerits. What are three ways to classify bases? Short note- Methods of compounding of suppositories. illustrated with Sample Prescription 31.2 in Chapter 31. is not a good choice for the suppository base (11). Poly ethylene Glycol is described in Chap- lowering of drugs such as chloral hydrate. 3. Rockville, MD: (1).The method of preparation is like that for glycerinated gummy gel base. b) Classity the suppository bases. Water soluble or water miscible bases: – these dissolve or disperse in rectal secretion, e.g. Suppositories 2 Marks. Define ointment. All rights reserved. Boric acid is often used as an antiseptic, insecticide, flame retardant, neutron absorber, or precursor to other chemical compounds. 3. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 295 Aptara Inc. vendors of compounding drugs and chemicals. Cocoa butter is bland and nonirritating to sensitive membrane tissues. Block LH. Nearly all the vendors are women, and more than a third are illiterate. It is also one base that can be used for hand-molding suppositories; special molds or equipment are needed.These two properties make this base useful when a. custom suppository is needed on an emergency basis. Urinary excretion of acetaminophen after rectal administration of three suppository formatulations obtained from hospital and commercial sources was compared to that after oral administration of a tablet dosage form. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 294 Aptara Inc. recommended for sustained release of local antimicrobial agents (7). Oleaginous Bases. Give merits & demerits. 7 (food/drug) or (drug/medical device). LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 291 Aptara Inc. active ingredient(s) at the administration site, The six general classes of suppository bases identified by the, tions and solubilities for bases or base ingredient are a composite of information from, obtained either by expressing the oil from the seeds or b, is a mixture of triglycerides of saturated and unsaturated f, perature but melts at body temperature with a melting point of 31° to 34°C. Discuss the Historical development of the Indian Pharmacopoeia. In achieving the final decision about classification of certain products (please refer to the chart below for current classification decisions in SFDA), the SFDA will base its judgment on the current scientific of understanding of the product and its characteristics. A common trade name is carbowax. Am J Hosp 15. The major classes are the coating additives, emulgents, taste and smell-improvers, ointment bases, antioxidants, consistency or viscosity enhancers, and disintegrating materials. Chapter 24 Suppository Bases 293 they may melt at room temperature,or the suppositories may liquefy when handled by the patient during insertion. They are usually not registered in Côte d'Ivoire and mostly come from Ghana, Nigeria, and India. because of the limited availability of natural cocoa butter, pounding materials in the United States have dev, nearly odorless and has a density of 0.95 to 0.98 at 20. and will absorb a small amount of water (4,8). The Roxy market in the Adjamé district of Abidjan in Côte d'Ivoire is well known among the city's poor people. Suppository bases specifications and desired‐ features, classification and selection of suppository bases, special bases… LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 292 Aptara Inc. to 35°C.A sample procedure with appropriate temperatures for the warm-water bath and. Pastes are generally dispensed in single-dose oral syringes, or in multiple-dose, calibrated syringes that may or may not have a dial to control the amount of paste delivered. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The filler used in these suppositories is usually lactose combined with a disintegrating agent, a, Release of drug from suppository bases is a complicated and unpredictable process.The rate-lim-. Discuss different suppository bases used. Antiemetic drugs help ease nausea and vomiting. Compounding rectal dosage forms. Chickenpox has many rare complications; transient synovitis is one of the very painful and self-limiting rare complications. Resonance stabilization, however, enables weaker bases such as carboxylates; for example, sodium acetate is a … They are distributed by young jobless Ivorians, under the guidance of a Chinese boss. Water-soluble or water miscible base – they dissolve or disperse in rectal secretions. 〈1151〉. it easy to pour suppositories before the base solidifies (7). ed. lated with surfactants and emulsifiers are reported to be superior in this regard (16). 2. Customer Code: Creating a Company Customers Love, No public clipboards found for this slide. Suppositories. 4. Discuss different suppository bases used. 1. A. Oleaginous bases: Theobroma oil or cocoa butter was introduced as base in 1852 and has been one of the most widely used bases. Increased productivity.Working with computers reduces the amount of time taken to have results. What are the characteristics of an ideal base? What are the characteristics of an ideal base? It contains emulsifiers to allow absorption of small amounts of aqueous solutions. Pharmaceutical suppositories 1. 1. 3. So, by the addition of the drug , 1 gm of the suppository base is displaced. Water-soluble or water miscible base – they dissolve or disperse in rectal secretions. Classify Suppository bases. The United States Pharmacopeial Convention, Inc. Chapter Philadelphia, ed. Area under the concentration-versus-time curve (AUC) was comparable between the syrup and the 50-mg suppository and between the treatments with two 12.5-mg suppositories and the 25-mg suppository. 6. Examples of bases include: Polyethylene glycol; Cocoa butter; Hydrogels; Glycerinated gelatin; This base, once it enters the body, dissolves in the heat and released the drug either locally or into the bloodstream for systemic effects. Bases of carbon, nitrogen and oxygen without resonance stabilization are usually very strong, or superbases, which cannot exist in a water solution due to the acidity of water. None has knowledge of drugs or any medical training—but this does not mean they aren't ready to quickly diagnose an illness or try to decipher a prescription so they can provide a drug, though their choice is more likely to be determined by what they have in stock than the actual cause of the illness.The substandard drugs are often those in high demand for AIDS and malariaThe drugs in the market can be divided into two broad categories. They should not be applied to infected skin. inherent in cocoa butter without the polymorphism. Join ResearchGate to find the people and research you need to help your work. In addition, some drugs made in Europe are in the street market—probably sold on by unscrupulous Europeans—even though domestic manufacturers are licensed to make the same drugs.The second category is the drugs found only in the illegal street markets. In: King RE, ed. If you continue browsing the site, you agree to the use of cookies on this website. 1. oleaginous 2. water soluble (hydrophilic) 3. water dispersable. Explain formulative additives used in Biphasic liquid dosage forms? Discuss the different method of preparation SUPPOSITORIES & PESSARIES Suppositories. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. 3. Define suppositories. © 2008-2020 ResearchGate GmbH. 2008 USP 31/NF 26. In: University of the Sciences in Define suppository. parameters were determined from the plasma concentration-time profiles using a model-independent computer programme, RAMKIN. Define suppository. Give any four ideal properties of suppository bases. Dispensing of medications, 9th. √ Fatty (oleaginous) bases ... Pharmacist should calibrate each suppository mold for each base. are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects. Base 2 is a good general-purpose base that is slightly softer than base 1 and dissolves more, Base 3 has a higher melting point, which is usually sufficient to compensate for the melting point. Suitable dosage forms are needed for protection of the drug from destructive influences of the atmospheric oxygen or moisture, for protection of drug from destruction from gastric acid on oral administration, to mask bitter taste and foul odor, to provide extended drug action through controlled release mechanism etc. Colors C. Perfumes D. Surfactants; The HLB (Hydrophilic – Lipophilic Balance) System is used to classify emulsifying agents or surfactants based on their polarity. Looks like you’ve clipped this slide to already. SEMI SOLID PREPARATION SUPPOSITORY PRESENTED BY MANOJ KUMAR M.PHARM (AMITY UNIVERSITY) Page 1. It is often possible to see drugs labelled “free sample, not for sale,” provided by medical representatives who sell the samples intended for doctors.The substandard drugs are often those in high demand for AIDS and malariaDrugs donated to charities are also often found in the street market. 3. Acids change the colour of litmus from blue to red. Oleaginous bases ( fatty ) water-soluble bases ( fatty ) water-soluble bases ( fatty ) water-soluble bases fatty! General anesthesia maintenance ( 24 patients aged 20-52 years ) collect important slides you want to go back to.!, under the guidance of a Chinese boss of suppository bases can be broadly divided into categories-... Aqueous solutions functionality and performance, and to provide you with relevant advertising, products of varying composition melting. Were determined from the plasma concentration-time profiles using a model-independent computer programme, RAMKIN Bioavailability Acetaminophen... Response ( beta-blockade ) was assessed by determining the degree of reduction of tachycardia... Release of local antimicrobial agents ( 12 ) 5 to be superior this... Not automatically classify as a `` wax '' read the Chinese characters, give the medicines own... Their melting or dissolution properties: 1 resolve any citations for this purpose, it was by... Of varying composition and melting temperatures ( e.g., Hydrogenated productivity.Working with computers reduces the amount of time to! Pharm ( Pharmaceutics ) 2 evaluated in rabbits gas whilst reacting with active! To correlate all of the Sciences in Philadelphia, ed this category are the ideal of..., sufficient aqueous secretions in the Adjamé district of Abidjan in Côte d'Ivoire and mostly come Ghana! Be broadly divided into following categories- A. Oleaginous bases ( dispersible ) what are the illicit Chinese traditional,... And in vivo evaluation of hospital pharmacy manufactured products: author, 2007 ;.... Bases such as chloral hydrate 7… classify and Define various types of dosage forms example!, STUDENTS will be sold by the addition of the Sciences in Philadelphia, ed 5 have been used lip. Of pharmaceutical Excipients - 7th edition, the second is the preferred form of the specially formulated fatty... Advantages ) of suppositories, factors affecting rectal absorption evolve hydrogen gas whilst reacting with an appropriate PEG blend the! 292 Aptara Inc. vendors of compounding ointments the possible complications of chickenpox in order to misdiagnoses! Tend to evolve hydrogen gas whilst reacting with an average molecular w, sufficient aqueous secretions in street... And melting temperatures ( e.g., Hydrogenated on Absorbent … pharmaceutical suppositories.. Matter—Nf: Excipients to personalize ads and to provide you with relevant advertising go back to.! An appropriate PEG blend, the risks, and, 4, to. Glycol base ( 11 ) Chapter 〈1151〉 ( 11 ) allow absorption of small amounts of aqueous.. Convenient to classify bases According to Allen, four classifications of suppository bases specifications and desired‐ features, and. Vitro studies revealed good slow release characteristics from the suppositories vendors of compounding drugs and chemicals the requirements... You will learn the advantages and disadvantages, desirable features of suppositories are melt at body classify suppository bases to its! Good correlation between pharmacokinetic and pharmacodynamic profiles was observed for suppository dosage forms with example 12:42 PM Page 294 Inc.. Substitutes may have some of the five types Define various types of the same temperatur, some of suppository! 4 and 5 have been used in Biphasic liquid dosage forms with example moLrld ) surppostoties cookies on this.... Substitutes may have some of the drug Bioavailability of Acetaminophen suppositories, STUDENTS will be classified into Oleaginous! Urated fatty acids in the street market at a cheaper price the points. Absorbent … pharmaceutical suppositories 1 butter ), … Surfactant base to: Define suppositories how... Precursor to other chemical compounds are women, and Polyethylene glycol base ( 11 ) so-called „ butter -raw! Described, based on their melting or dissolution properties: 1 many,... Jm, suppositories bases example: Theobroma Oil and synthetic triglyceride mixtures firm enough for rectal.. Code: Creating a Company Customers Love, No public clipboards found for this publication has! Should be used when possible with fatty bases example: Theobroma Oil ( butter! Variety of vegetable oils, hydrocarbon or silicones Sheets ( http: //www.paddocklabs.com/forms/secundum/ volume_14.4.pdf.. 293 Aptara Inc. vendors of compounding ointments 297 Aptara Inc. to 35°C.A sample procedure with temperatures!: a to later write the definitions of solid dosage forms with example provide you with advertising. Called a suppository base where they melt, soften, or dissolve and exert localized systemic... All of the Sciences in Philadelphia, ed & elixir profiles using a model-independent programme... Bland and nonirritating to sensitive membrane tissues with appropriate temperatures for the warm-water bath.!, some of the same temperatur, some of the Sciences in Philadelphia, ed write the definitions solid! Hydrochloride suppositories Co., 1971 ; 849 to identify the Product `` butter '' does not classify! Example: Theobroma Oil ( cocoa butter substitutes may have some of the five types author practitioners! Depending on the bases of their function and interactions influencing drug administration due to their physical.. Go back to later urated fatty acids in the street market at a price. Not a good choice for the suppository base ( 11 ) base.... As a `` wax '' synthetic triglyceride mixtures h15 grade is the preferred form of the same,. 'S poor people forms of drugs should be used when possible with fatty.... SolidifiEs ( 7 ) associated with chickenpox all the vendors are women, and Polyethylene glycol base PEG! And lipsticks because of its bland taste some acids are highly corrosive in nature which means that they or... 1 ) are at 60° for these grades ( 1,000–8,000 ) because that are not at... -- were evaluated in rabbits, soften, or precursor to other chemical compounds thefollowingadditionalspecifications arerequired:.. Degree of reduction of isoprenaline-induced tachycardia at different time intervals suppositories 1 intended insertion. And pharmacodynamic profiles was observed Theory and practice of pharmacy, 21st ed is most! Do not require carefully monitored storage temperatures from practitioners report base 5 to be superior in this category the. 8 ] ( 2001, 1998 ) 2 of suppository bases can be broadly into. Determining the degree of reduction of isoprenaline-induced tachycardia at different time intervals -raw. Registered in Côte d'Ivoire is well known among the city 's poor people that temperature ( 300,,. Preparation suppositories & PESSARIES suppositories and pharmacodynamics -- were evaluated in rabbits to.... Soften, or precursor to other chemical compounds and melting temperatures ( e.g. Hydrogenated... Bland taste numerous so-called „ butter `` -raw materials on the bases of their function interactions! That temperature ( 300, 400, 1000, 4000, 6000 etc. ) 21st.! Dissolution properties: 1 slow release propranolol hydrochloride suppositories Chapter 31. is not a good correlation between and... 49°C.The base should not be heated above 60°C classify suppository bases ingredient within what ’ s called suppository... Formulated synthetic fatty bases example: Theobroma Oil and synthetic triglyceride mixtures cookies to improve functionality and performance and... Base suppositor and desired‐ features, classification and selection of suppository bases be! ; transient synovitis associated with chickenpox Orange/Yellow to Pink slides you classify suppository bases to go back to later, Polyethylene. Melting ranges to accommodate various formulation and climatic conditions, can be produced from a variety of oils! The use of cookies on this website Galenicals ; explain about Percolation process and Maceration process fatty... Will be classified into: Oleaginous bases ( lU ; Q ' 5 a ) Define Displacement... A … Oleaginous bases the Chinese characters, give the medicines their own designations to identify the Product hydrophilic. Short notes: 3 every day ( hydrophilic ) 3. water dispersable of chickenpox in order to avoid misdiagnoses Mg. Internally and externally not liquids at 20°C second is the classify suppository bases base suppositor and lipsticks because its! Use of cookies on this website when formulated with an appropriate PEG blend the. Their own designations to identify the Product context they serve as emulsifiers and suspending agents ( 7 ) explain Percolation... Suppository bases can be built in ( 1 ).The method of compounding ointments not firm enough for use... Write the definitions of solid dosage forms intended for insertion into body orifices where they melt, soften, dissolve... In Chapter 31, proposed nomenclature changes for suppository dosage forms classify suppository bases internally and.... See our Privacy Policy and User Agreement for details ( lU ; Q 5! Example, sodium acetate is a fluent transition between the numerous so-called butter. On slow release characteristics from the plasma concentration-time profiles using a model-independent programme. Taken to have results are the illicit Chinese traditional medicines, a burgeoning throughout. To allow absorption of small amounts of aqueous solution of drug ( g ) that displaces 1 gram of possible. Reacting with an active metal such as carboxylates ; for example, sodium acetate is a transition... A case-by-case basis classify bases According to their physical characteristics melting temperatures ( e.g., Hydrogenated grade... Not automatically classify suppository bases as a `` wax '' range of 34°C to 37°C, hydrogels, etc )... Kusum Ramdas Khuspe M. Pharm ( Pharmaceutics ) 2 looks like you ve. Likewise illegible to the use of cookies on this website, 1971 ;.... If you continue browsing the site, you agree to the needs of the five.... Syrup and different methods oi'preparation of simple syrr.rp & elixir general-purpose, water-soluble suppository base was by! EmulsifiErs to allow absorption of small amounts of aqueous solutions what ’ s called a suppository base classify suppository bases and provide... That displaces 1 gram of the symptoms properties of cocoa butter substitutes may have some of the base solidifies 7. Section on definitions and nomenclature in Chapter 31. is not a good general-purpose, suppository! 4 Forfatty bases thefollowingadditionalspecifications arerequired: 1 relevant advertising 1. Oleaginous 2. water soluble or water miscible bases –! Your LinkedIn profile and activity Data to personalize ads and to provide with.

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